Hydrogen increases Insulin activity in skeletal muscle, helping the body use Glucose more efficiently. Hydrogen also reduces Glucose production from the liver, which helps lower blood Glucose levels. – Study titled: Hydrogen improves glycemic control in a Type 1 Diabetes animal model by promoting glucose uptake into skeletal muscle. – By the scientists Haruka Amitani, Akihiro Asakawa in 2013.
Study Title: Hydrogen Improves Glycemic Control in a Type 1 Diabetes Animal Model by Promoting Glucose Uptake into Skeletal Muscle
Scientists Haruka Amitani, Akihiro Asakawa. Published in 2013.
Kajiyama et al. conducted a randomized, double-blind, placebo-controlled crossover study in 30 patients with Type 2 Diabetes and 6 patients with impaired Glucose Tolerance. The patients consumed 900 mL of H2 water or placebo water for 8 weeks, with a 12-week washout period. Statistical significance was observed in the improvement of negatively-charged low-density lipoprotein (LDL)-cholesterol, small dense LDL, and urinary 8-isoprostanes. In four of the six patients with impaired glucose tolerance, H2 improved their oral glucose tolerance test results to normal levels.
 
Study: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with Type 2 Diabetes or impaired glucose tolerance” (Kajiyama S et al., 2008).
Based on the observation that acarbose induces endogenous H2 production, Suzuki et al. found that acarbose treatment increases exhaled H2 concentration, reducing the risk of cardiovascular disease in patients with impaired glucose tolerance or Type 2 Diabetes. These benefits can be attributed, at least in part, to acarbose’s ability to neutralize oxidative stress by increasing H2 production in the gastrointestinal tract. Amitani et al. demonstrated that H2 can produce metabolic effects similar to Insulin and may also be a new therapeutic option for Type 1 Diabetes.
 
Study: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with Type 2 Diabetes or impaired glucose tolerance
Authors: Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T. Published 2008 in Nutr Res
Impaired renal uric acid excretion is the major mechanism of hyperuricemia in patients with primary gout. This review highlights recent advances in the knowledge of normal mechanisms of renal uric acid handling and derangement of these mechanisms in uric acid underexcretion.
 
Study: Control of renal excretion of uric acid and gout
Taniguchi A, Kamatani N. Curr Opin Rheumatol. Published 2008
The study demonstrated that H2 gas inhalation therapy reduces bone marrow injury caused by intensity-modulated radiation therapy (IMRT) without compromising the anti-tumor effects of IMRT. The study also showed that H2 gas inhalation therapy has the potential to protect against IMRT-induced bone marrow damage in cancer patients.
Study: Protective effects of hydrogen gas inhalation on radiation-induced bone marrow injury in cancer patients: a retrospective observational study
Authors: Hirano, Shin-ichi; Aoki, Yukimasa; Li, Xiaokang; Ichimaru, Naotsugu; Takahara, Shi; Takefuji, Yoshiyasu,* 2021
Hydrogen-rich water has the potential to mitigate liver damage caused by mFOLFOX6* chemotherapy in colorectal cancer patients.
Study: Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
Authors: Qingxi Yang Guangxin Ji Rongtao Pan Yinghui Zhao Peng Yan
Online publication date: September 1, 2017
*mFOLFOX6 chemotherapy is a combination of different chemotherapeutic agents, each with a distinct effect on killing cancer cells.
This study provided preliminary evidence on the effectiveness of hydrogen gas in reducing the ratio of PD-1+ CD8+ T cells and improving the prognosis of patients with advanced colorectal cancer.
(Improving the prognosis of cancer patients is understood as helping to: prolong survival, reduce symptoms, enhance quality of life, and increase survival rate).
Study: Immunological effect of hydrogen gas – Hydrogen gas improves clinical outcomes of cancer patients
Author: Akagi J, Gan to Kagaku ryoho. Cancer & Chemotherapy, 01 Oct 2018
Daily consumption of **Hydrogen-rich water** may be an effective adjunctive method during **radiation therapy** for cancer patients. Hydrogen-rich water helps improve **Quality of Life (QOL)** by reducing the **oxidative stress** caused by radiation, without compromising the effectiveness of the cancer treatment.
Study: Effect of **hydrogen-rich water** on **Quality of Life** of patients treated with **radiation therapy** for **liver cancer**
Authors: Ki-Mun Kang, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda & Atsunori Nakao, 2011.
Oxidative stress is associated with the progression of **Parkinson’s disease (PD)**. Recent studies have confirmed that **molecular hydrogen (H2)** acts as a highly effective **antioxidant** in cultured cells and animal models. Drinking H2-dissolved water (**H2-water**) reduces **oxidative stress** and improves Parkinson’s disease.
Study: Pilot Study of H2 Therapy in Parkinson’s Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Asako Yoritaka, MD, PhD, Masashi Takanashi, MD, PhD, Masaaki Hirayama, MD, PhD, Toshiki Nakahara, MD, PhD, Shigeo Ohta, PhD, Nobutaka Hattori, MD, PhD
First published: February 11, 2013
H2 water may have the potential to inhibit **dementia** in an oxidative stress model and in APOE4 carriers with **Mild Cognitive Impairment (MCI)**.
Study: Impact of **molecular hydrogen** as evaluated by animal model and randomized clinical study on **mild cognitive impairment**
Authors: Kiyomi Nishimaki, Takashi Asada*, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura, and Shigeo Ohta* 2018
**Hydrogen-rich water** significantly reduced the concentration of **inflammatory substances** in the brains of mice with **Alzheimer’s disease**. Mice treated with hydrogen-rich water showed better **learning and memory** abilities compared to the control group. Hydrogen-rich water reduced **free radical-induced cell damage**.
Study: Hydrogen-rich saline improves memory function in an amyloid-beta induced Alzheimer’s disease mouse model by reducing oxidative stress.
Jian Li, Cai Wang, John H. Zhang, Jian-Mei Cai, Yun-Peng Cao, Xue-Jun Sun, 2010
Hydrogen helped improve **oxygen saturation**, reduced the severity of brain lesions on MRI, lowered the stroke severity score (**NIHSS**), showed improved stroke symptoms, and enhanced mobility as measured by a patient’s ability to care for themselves in activities of daily living (**Barthel Index**).
Study: Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized, Controlled Clinical Trial for Safety and Neuroprotection
Authors: Hirohisa Ono, Yoji Nishijima, Shigeo Ohta, Saori Okamoto, Shou Ishii, Hiroko Takanami et al.
2017
**Liver fibrosis** is a common consequence of chronic liver diseases, and prolonged **hepatocyte damage** leads to an inflammatory response. The inhibition of **liver fibrosis** mediated by Hydrogen is achieved by selectively scavenging **free radicals**, which protects liver cells from damage — According to the study “Effect of drinking Hydrogen water on the progression of **liver fibrosis** in rats” by Koyama Y, Taura K, et al., 2014.
Study: “Effect of drinking Hydrogen water on the progression of liver fibrosis in rats”
Authors Koyama Y, Taura K, et al., 2014.
**Liver fibrosis** is a common consequence of chronic liver diseases, and prolonged **hepatocyte damage** leads to an inflammatory response. The inhibition of **liver fibrosis** mediated by Hydrogen is achieved by selectively scavenging **free radicals**, which protects liver cells from damage — According to the study “Effect of drinking Hydrogen water on the progression of **liver fibrosis** in rats” by Koyama Y, Taura K, et al., 2014.
Study: “Effect of drinking Hydrogen water on the progression of liver fibrosis in rats”
Authors Koyama Y, Taura K, et al., 2014.
Seven studies met the inclusion criteria, totaling 279 participants. The main finding of this research is that the consumption of **Hydrogen-Rich Water** had a significantly positive effect on reducing **serum total cholesterol**, lipoprotein levels, and **triglycerides**.
In summary, this study shows that the intake of **Hydrogen-Rich Water** significantly improves several factors in the **blood lipid profile** across various clinical populations. Hydrogen-rich water may impact cellular energy production and **lipid metabolism**, which play a role in cellular regulation.
Study: The impact of **hydrogen-rich water** on **blood lipid profile** in clinical populations: A systematic review and meta-analysis
Authors: Nikola Todorovic1, Julen Fernández-Landa2ORCID, Asier Santibañez2ORCID, Branislav Kura3ORCID, Valdemar Stajer1ORCID, Darinka Korovljev1ORCID, and Sergej M. Ostojic1,4,5,* 2023
This study showed that drinking **hydrogen-rich water** significantly reduced **total cholesterol (TC)** and **LDL cholesterol (LDL-C)**; it protected LDL from oxidation, inhibited the adhesion of **mononuclear cells** to **endothelial cells**, stimulated **cholesterol efflux** from **macrophage foam cells**; it protected endothelial cells from damage, increased **antioxidant enzymes**, and reduced **oxidative substances**.
Study: Hydrogen-rich water reduces **serum LDL-cholesterol** levels and improves **HDL function** in patients with potential **metabolic syndrome**
Authors: Guohua Song, Min Li, Hui Sang, Chuanlong Zong, Yazhuo Xue, Shucun Qin, et al. 2013
Supplementation with **high-concentration Hydrogen-rich water** significantly reduced **blood cholesterol and glucose levels**, lowered **serum HbA1c levels**, and improved the status of **inflammation** and **redox balance**. Furthermore, Hydrogen tended to promote a modest reduction in **body weight** and **waist-to-hip ratio**.
Study: The effects of 24-week **high-concentration hydrogen-rich water** on **body composition**, **blood lipid profile**, and inflammatory biomarkers in men and women with **metabolic syndrome**: A randomized controlled trial
Authors: LeBaron TW, Singh RB, Fatima G, Kartikey K, Sharma JP, Ostojic SM, Gvozdjakova A, Kura B, Noda M, Mojto V, Niaz MA, Slezak J. Published 2020
**Hydrogen gas inhalation** is also believed to have a **protective effect** against **I/R injury** in the liver — According to the study “Hydrogen gas inhalation prevents **ischemia/reperfusion-induced liver injury** through reducing **oxidative stress**” by Fukuda K, Asoh S, Ishikawa M in 2007.
Study: Hydrogen gas inhalation prevents ischemia/reperfusion-induced liver injury through reducing oxidative stress
Authors Fukuda K, Asoh S, Ishikawa M, 2007
In the study titled “Hydrogen Sulfide Attenuates Carbon Tetrachloride-Induced Hepatotoxicity, Liver Cirrhosis and Portal Hypertension in Rats” by Gang Tan and Shangha Pan in 2011, it was demonstrated that **Hydrogen-rich water** has the potential to help **stabilize liver enzymes** and support the improvement of **hepatitis**, **liver cirrhosis**, and more.
Study: Hydrogen sulfide attenuates **carbon tetrachloride-induced hepatotoxicity**, **liver cirrhosis**, and **portal hypertension** in rats
Authors: Gang Tan, Shangha Pan, 2011
**Hydrogen/oxygen inhalation** improved **serum lipids** and **liver enzymes**. Significantly improved **hepatic fat content** on ultrasound and CT scans after hydrogen/oxygen inhalation was observed in moderate-to-severe cases. Hydrogen/oxygen inhalation reduced **Non-Alcoholic Fatty Liver Disease (NAFLD)** in patients with moderate-to-severe disease. This protective effect of hydrogen may be through the activation of hepatic phagocytosis.
Study: A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for the treatment of **Non-Alcoholic Fatty Liver Disease**
Authors: Geru Tao, Guangjie Zhang, Shen Wei, Chaoyang, et al., published June 23, 2022
Clinical studies have demonstrated the beneficial effects of **HRW** in subjects with **metabolic syndrome**. Similarly, a 28-day pilot study demonstrated that HRW reduced hepatic **lipid accumulation** in subjects with **NAFLD** without significantly affecting lipid parameters [ **12** ].
Study: **Hydrogen-rich water** reduces **hepatic fat accumulation** and improves **liver enzymes** in patients with **Non-Alcoholic Fatty Liver Disease**: A randomized controlled pilot trial.
Clin. Res. Hepatol. Gastroenterol. 2019